Technical aspects of an impact acceleration traumatic brain injury rat model with potential suitability for both microdialysis and PtiO2 monitoring. - SSA - Service de santé des armées Access content directly
Journal Articles Journal of Neuroscience Methods Year : 2004

Technical aspects of an impact acceleration traumatic brain injury rat model with potential suitability for both microdialysis and PtiO2 monitoring.

Emmanuel Cantais
  • Function : Author
Olivier Darbin
  • Function : Author
Jean-Pierre Terrier
  • Function : Author
Michel Lonjon
  • Function : Author
Bruno Palmier
  • Function : Author
Jean-Jacques Risso
  • Function : Author

Abstract

This report describes technical adaptations of a traumatic brain injury (TBI) model-largely inspired by Marmarou-in order to monitor microdialysis data and PtiO2 (brain tissue oxygen) before, during and after injury. We particularly focalize on our model requirements which allows us to re-create some drastic pathological characteristics experienced by severely head-injured patients: impact on a closed skull, no ventilation immediately after impact, presence of diffuse axonal injuries and secondary brain insults from systemic origin...We notably give priority to minimize anaesthesia duration in order to tend to banish any neuroprotection. Our new model will henceforth allow a better understanding of neurochemical and biochemical alterations resulting from traumatic brain injury, using microdialysis and PtiO2 techniques already monitored in our Intensive Care Unit. Studies on efficiency and therapeutic window of neuroprotective pharmacological molecules are now conceivable to ameliorate severe head-injury treatment.
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Dates and versions

ssa-00165574 , version 1 (26-07-2007)

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Emilie Carré, Emmanuel Cantais, Olivier Darbin, Jean-Pierre Terrier, Michel Lonjon, et al.. Technical aspects of an impact acceleration traumatic brain injury rat model with potential suitability for both microdialysis and PtiO2 monitoring.. Journal of Neuroscience Methods, 2004, 140 (1-2), pp.23-8. ⟨10.1016/j.jneumeth.2004.04.037⟩. ⟨ssa-00165574⟩

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